IS CURING PATIENTS A SUSTAINABLE BUSINESS MODEL? || Asks A Goldman Sachs’ Analyst

GOLDMAN SACHS: ‘IS CURING PATIENTS A SUSTAINABLE BUSINESS MODEL?’

via ★ Daringfireball (John Gruber)

Tae Kim, reporting for CNBC:

Goldman Sachs analysts attempted to address a touchy subject for biotech companies, especially those involved in the pioneering “gene therapy” treatment: cures could be bad for business in the long run.

“Is curing patients a sustainable business model?” analysts ask in an April 10 report entitled “The Genome Revolution.”

“The potential to deliver ‘one shot cures’ is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies,” analyst Salveen Richter wrote in the note to clients Tuesday. “While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow.”

Hard to think of a better example of what is turning capitalism into a dirty word. (Also, this is why we need government-funded research, to make the goal crystal clear: finding a cure, not finding profit.)

Susan Kare

Susan Kare, John Gruber - Layers 2015 from Layers Design Conference on Vimeo.

Susan discusses her history with Apple and icon design, and sits down with John Gruber to talk design.

iPhone 6S/6S + Review || DF

• John Gruber @ DF:

…


THE BOTTOM LINE

New-number iPhones (4, 5, 6) are about showing off Apple’s design prowess. The S models are about showing off Apple’s engineering prowess. Storage capacities and battery life are unchanged from last year’s iPhones. Everything else — the materials they’re made from, the performance of their custom CPU/GPU, the quality of the cameras, the smoothness of the user interface — is noticeably, tangibly improved.

John Gruber || The Talk Show Live From WWDC 2015

The Talk Show Live From WWDC 2015 from John Gruber on Vimeo.

Producer: Amy Jane Gruber @amyjane
Junior Producer & Announcer: Paul Kafasis @pbones
Directed & Edited by: App: The Human Story @appdocu
Audio Engineering by: Caleb Sexton @calebsexton
Webcast Production by: Hybrid Events Group @hybrideventsgrp

Shrill From Major Gruber @ Daring Fireball & Some Amicable Punches From The BeardLord @ The Loop + More || iPhone 5C & 5S Review

DaringFireball’s “CAN’T INNOVATE, MY ASS”, INDEED

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So what has Apple delivered with the iPhone 5S?

With the A7 they’ve doubled CPU performance in exactly one year, at no apparent cost to battery life. They’ve potentially obviated the need for standalone motion trackers like Fitbits and Nike Fuelbands. And they’ve started a transition to platform-wide 64-bit computing years ahead of their competition.

With Touch ID they’ve eliminated the need to enter a passcode to unlock your phone and a (one hopes) complex password to download apps and media from the iTunes Store. Mere conveniences, yes, but very nice ones indeed. They’ve also potentially set the stage for numerous future conveniences. Imagine Touch ID integrated with the upcoming iCloud Keychains.

With the camera they’ve created a simple, intuitive interface for taking bursts of fast action or won’t-stay-still kids and pets. It’s a wonderful hardware feat to put a 10 fps still camera in a remarkably thin mobile phone (a phone with no inelegant bulge to accommodate more distance between lens and sensor, at that). But the real innovation — there’s that word — is software, right there on the device itself, that makes it easy to select only the shots from those bursts that you really want to keep, and to throw away the rest.

This is what innovation, real innovation, looks like. It’s like the Thomas Edison quote, “Opportunity is missed by most people because it is dressed in overalls and looks like work.” Innovation is missed by most people because it is so often incremental.

…

From The BeardLord @ loopInsightDOTcom:

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There are a couple of reasons a company makes changes to its products. One is to improve it, making it better for its users; the other is to give people the perception of change in hopes of selling something shiny and new, when it really isn’t.

I’m all for new features, but if they don’t actually help me get things done more efficiently, then you have to ask, “what’s the point?” I ask myself that question quite a bit when I’m looking at any new product, including the new iPhones.

I must say, I’m quite happy with the answers I’ve come up with.

…

appleInsiderDOTcom’s ( Review RoundUp From Various Tech Sites ) iPhone 5s with iOS 7 best smartphone available!

- Shocking!

Hands On • iPhone 5C and iPhone 5S First Impressions By People Who Actually Know about Technology And Apple

John Gruber’s Thoughts and Observations on Today’s iPhone 5C and 5S Introduction


Jim Dalrymple’s Hands on with the iPhone 5C and iPhone 5S



Perhaps i’ll get the cheaper one.

Apple as Bumblebee || DaringFireball

John Gruber:

James Surowiecki had a piece on Apple in last week’s New Yorker; far better than Tim Wu’s ham-fisted “open beats closed” piece, but similarly flawed in terms of baseline assumptions:

Over time, Apple has succeeded despite (or because of) its disregard for the conventional wisdom about what works in technology markets: it has built hardware and software, kept its platform closed, had long product cycles, and emphasized quality over price. It’s always been the proverbial bumblebee: it shouldn’t be able to fly but it does. A wobble in flight is all it takes for people to proclaim its inevitable crash.

… I found this passage very telling. I have long argued that Apple’s business model is simple and seemingly obvious: make high-quality products that people want to buy and sell them for a profit. Yet many people continue to look at this and say, “That shouldn’t work”.